Stirling Moss and Mike Taylor were seriously injured in crashes during practice, and Chris Bristow and Alan Stacey were killed in accidents during the race.
On lap 20 Chris Bristow, driving a year-old Cooper for the British Racing Partnership, went off line at Malmedy while battling for sixth place with the Ferrari of Mairesse.
Five laps later, Alan Stacey was hit in the face by a bird at Masta, causing him to lose control with his car somersaulting off the track and landing in a field.
It was the only Formula One race meeting in which two drivers were killed until the deaths of Roland Ratzenberger and Ayrton Senna at the 1994 San Marino Grand Prix.
In fact the rule about crossing the finishing line was inconsistently applied – at the 1959 German Grand Prix, Harry Schell was classified seventh despite only completing 49 of the race's 60 laps.