A Zantop Air Transport Douglas DC-4 was on its final approach to Greater Cincinnati Airport runway 18 (now runway 18C), when it clipped some trees and crashed into a wooded area north of the airport.

[1] This was the first of at least three aircraft on their final approach that failed to reach runway 18 at the Greater Cincinnati Airport, becoming victims of the area's hilly terrain with steep changes in elevation from the Ohio River,[2] the others being American Airlines Flight 383 and TWA Flight 128.

The pilot, Calvin Goutier, the co-pilot, Richard Breathren, and the unnamed flight engineer were flying from Detroit, Michigan, carrying automotive parts for General Motors Corporation to the airport for a routine landing while en route to Atlanta, Georgia.

A passing motorist, who worked for Delta Air Lines, noted a person walking out of the woods and continued driving to the airport.

Zantop Air Transport bought the aircraft in June 1960 and operated it as a cargo plane until it crashed.