The 16th Vuelta a España (Tour of Spain), a long-distance bicycle stage race and one of the three grand tours, was held from 26 April to 11 May 1961.

It consisted of 16 stages covering a total of 2,856.5 km (1,774.9 mi), and was won by Angelino Soler of the Faema cycling team.

[1] Antonio Suárez won the points classification and Antonio Karmany won the mountains classification.

General classification(la roja) Points classification(jersey verde) Mountains classification(jersey puntos azules) Young rider classification(jersey blanco) Team classification(clasificación por equipos) Combativity award