The 1963 NCAA University Division basketball tournament involved 25 schools playing in single-elimination play to determine the national champion of men's NCAA Division I college basketball in the United States.

It began on March 9, 1963, and ended with the championship game on March 23 in Louisville, Kentucky.

Loyola University Chicago, coached by George Ireland, won the national title with a 60–58 overtime victory in the final game, over the University of Cincinnati, coached by Ed Jucker.

Art Heyman, of Duke University, was named the tournament's Most Outstanding Player.

This tournament marked the last time that a city was host to two straight Final Fours.