In its fifth season under head coach Bill Yeoman, the team compiled an 8–2 record, outscored opponents by a total of 335 to 125, and was ranked No.
[4] Other statistical leaders included quarterback Bo Burris with 1,666 passing yards and split end Ken Hebert with 38 receptions, 800 receiving yards, and 113 points scored (11 touchdowns, 41 extra points, and two field goals).
[8] Houston players set multiple single-season school records during the 1966 season, including the following: The team also set single-game scoring and total offense records with 73 points and 585 yards against Tulsa on November 5.
[13] Several players from the 1966 Houston team later played in the NFL or AFL: Tom Beer, Bo Burris, Carl Cunningham, Paul Gipson, Ken Hebert, Greg Brezina, Charlie Hall, Gus Hollomon, Royce Berry, Warren McVea, and Dickie Post.
In addition, Tom Paciorek, who intercepted six passes in 1966,[21] went on to play 18 years in Major League Baseball.