The 1966 Pro Bowl was the National Football League's sixteenth annual all-star game which featured the outstanding performers from the 1965 season.

[3] The Western Conference stars were led by Vince Lombardi, head coach of the league champion Green Bay Packers.

[4] During the 1965 season, the Western Conference had dominated the Eastern Conference — Western teams were 13–1 in regular season inter-conference games and had won the league championship two weeks earlier, the third-place Playoff Bowl, and the previous two editions in this series.

[5] In his place, San Francisco 49ers quarterback John Brodie threw a record six interceptions, offset with one touchdown pass late in the game to Tommy McDonald of the Los Angeles Rams to avoid a shutout.

[3] One story line entering the game never materialized, the anticipated showdown between Brown and halfback Gale Sayers of the Chicago Bears, the season's consensus Rookie of the Year; Lombardi surprisingly called only a single play for Sayers, a handoff which gained fifteen yards.