The 1968 Cal Poly Mustangs football team represented California Polytechnic State College—now known as California Polytechnic State University, San Luis Obispo—as a member of the California Collegiate Athletic Association (CCAA) during the 1968 NCAA College Division football season.
Led by first-year head coach Joe Harper, Cal Poly compiled an overall record of 7–3 with a mark of 2–2 in conference play, tying for second place in the CCAA.
The Mustangs played home games at Mustang Stadium in San Luis Obispo, California.
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