Charleston County Republican Party chairman James B. Edwards was prepared to run in the general election had George A. Payton, Jr. won the Democratic primary.

[2] Incumbent Republican Congressman Albert Watson of the 2nd congressional district, in office since 1963, defeated Democratic challenger Frank K. Sloan.

Incumbent Democratic Congressman William Jennings Bryan Dorn of the 3rd congressional district, in office since 1951, defeated Republican challenger John Grisso.

Incumbent Democratic Congressman Robert T. Ashmore of the 4th congressional district, in office since 1953, opted to retire.

James R. Mann won the Democratic primary and defeated Republican challenger Charles Bradshaw in the general election.