[4][5] The collision led to outcry from politicians and citizens calling for traffic safety and infrastructure improvements, such as highway widenings, and the completion of Interstate 81 in Tennessee.

With this, the highway experienced extreme congestion that was not suitable for its then existing two-lane, curvy design and 65 miles-per-hour speed limit between Knoxville and Bristol, leading to a high number of collisions with severe injuries and fatalities.

[13] The NTSB concluded that the probable cause of the collision was the Greyhound bus driver's attempt to pass the automobile with the view of the westbound semi-truck being obstructed.

[1] The stretch of US 11W where the collision had occurred was not featured with double yellow lines, which possibly led to the bus driver attempting to pass the slow-moving automobile ahead of it.

[1] The NTSB concluded the report with recommendations on seat belt legislation for bus passengers, and impact protection advancements on interior paneling surrounding windows on buses.

[1] Led by the widow of one of the passengers aboard the bus, survivors of the crash and other family members of the victims filed a federal lawsuit against Greyhound Lines for $2.5 million.

[4] In 1973, one year following the collision, Tennessee legislators from the House and Senate chambers formed a special-joint investigation committee into the crisis regarding 11W and its ill-fated past.

In 2020, TDOT had begun the right-of-way acquisition phase of the 11W widening project between Rutledge and Bean Station, expecting to begin construction in 2021–2022.