The 1972 U.S. Professional Indoor – singles was an event of the 1971 U.S. Professional Indoor men's tennis tournament played at the Spectrum in Philadelphia in the United States from February 8 through February 13, 1971.

The draw comprised 32 players and 8 of them were seeded.

John Newcombe was the defending singles champion but lost in the second round.

First-seeded Rod Laver won the title, defeating second-seeded Ken Rosewall in the final, 4–6, 6–2, 6–2, 6–2.