But Richard Petty, who was out of the points because of a shoulder injury suffered at Darlington in May, was considered the favorite to win the race.
Isaac, in the Nord Krauskopf's K&K Insurance Dodge, led 179 laps and took the win by six car lengths over Petty.
Isaac advanced to become the 1970 Winston Cup Champion at season's end, with Allison being the runner-up in points.
Tiny Lund, driving a 1970 Camaro, qualified sixth and led just seven laps on his way to the victory.
Dave Marcis finished fourth, two laps down, and Benny Parsons rounded out the top five.
Bobby Allison was the only other driver to lead, running 11 laps out front before losing an engine prior to the half.
Richard Petty and Bobby Allison swapped the lead for the rest of the race, beating and banging each other for the win.
In the Gwyn Staley 400 of 1973, Bobby Allison landed on the pole with a qualifying lap of 21.077 seconds / 106.750 MPH.
Yvon DuHamel, a top AMA road racer from Quebec, drove a Mercury prepared by Junie Donlavey and finished in tenth place in his only career Cup race.
McDuffie, Lennie Pond, Dick Brooks, Dave Marcis, Richard Childress and Walter Ballard.
[2] Yarborough set an average speed of 96.858 miles per hour (155.878 km/h) for the event;[3] he described the race as a turnaround for his team, which had struggled, by his standards, up to that point in the 1976 season.
[4] Marcis, who was described as having his "best season ever" to that point in the year,[5] earned the pole position for the event, setting a speed of 108.585 miles per hour (174.751 km/h) in his Dodge during solo qualifying runs; Marcis' time set a new track record speed, with Parsons and Darrell Waltrip also breaking the old track record.
[7] Bill Champion would retire from NASCAR competition following the event,[8] along with last-place finisher Jeff Handy.