46 teams contested, beginning on 8 October 1977 and ending at the final on 5 May 1978.
FC Twente unsuccessfully defended its 1977 title at the Second round losing to Go Ahead Eagles, 2–1 (aet.
AZ'67 from Alkmaar (at the time called AZ'67) successfully pursued on 5 May 1978 in Olympisch Stadion, Amsterdam its first KNVB Cup losing to Ajax, 1–0.
1 Eerste Divisie; A Amateur teams The matches of the second round were played on November 19 and 20, 1977.
The quarter finals were played between February 1 and March 15, 1978.