It measured 0.625 miles (1.006 km) and featured a unique uphill backstretch and downhill frontstretch.
But Richard Petty, who was out of the points because of a shoulder injury suffered at Darlington in May, was considered the favorite to win the race.
Isaac, in the Nord Krauskopf's K&K Insurance Dodge, led 179 laps and took the win by six car lengths over Petty.
Isaac advanced to become the 1970 Winston Cup Champion at season's end, with Allison being the runner-up in points.
Bobby Allison was the only other driver to lead, running 11 laps out front before losing an engine prior to the half.
Richard Petty and Bobby Allison swapped the lead for the rest of the race, beating and banging each other for the win.
In the Gwyn Staley 400 of 1973, Bobby Allison landed on the pole with a qualifying lap of 21.077 seconds / 106.750 MPH.
Yvon DuHamel, a top AMA road racer from Quebec, drove a Mercury prepared by Junie Donlavey and finished in tenth place in his only career Cup race.
In 1975 the NASCAR Baby Grand Series, later known as Goody's Dash Series, ran its first race at North Wilkesboro, with a win by Dean Combs Richard Petty, Darrell Waltrip, Benny Parsons, and Cale Yarborough would constantly compete for the lead in this 400-lap event.
[2] After two hours and fifty-nine minutes of racing, Darrell Waltrip would defeat Cale Yarborough by slightly more than seven seconds in front of a live audience of eleven thousand people.
[2] The winner of the race would drive at speeds averaging up to 86.713 miles per hour (139.551 km/h) in the actual event.
Notable crew chiefs who actively participated in the race included Buddy Parrott, Jake Elder, Joey Arrington, Kirk Shelmerdine, Dale Inman, Harry Hyde, and Tim Brewer.