The 1978 East Tennessee State Buccaneers football team represented East Tennessee State University as a member of the Ohio Valley Conference (OVC) during the 1978 NCAA Division I-AA football season.
Led by first-year head coach Jack Carlisle, the Buccaneers compiled an overall record of 4–7, with a mark of 2–5 in conference play, and finished tied for fifth in the OVC.
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