The 1978 NCAA Division II baseball tournament was the postseason tournament hosted by the NCAA to determine the national champion of baseball among its Division II colleges and universities at the end of the 1978 NCAA Division II baseball season.
[1] Florida Southern defeated Delta State in the championship game of the double-elimination tournament, 7–2, winning the Moccasins' fourth national title.
The top team in each bracket advanced to the 1978 Division II College World Series.
Assumption (0–2) New Haven won regional Le Moyne (3–1) Shippensburg (3–2)
Saint Leo (1–2) Eckerd (0–2) Florida Southern won regional Eastern Illinois (4–1) Western Illinois (2–2) Wright State (1–2) Indianapolis (0–2) Eastern Illinois won regional Southwest Missouri State (3–0) Northwest Missouri State (2–2)