The 1979–80 Louisville Cardinals men's basketball team represented the University of Louisville during the 1979–80 NCAA Division I men's basketball season, Louisville's 66th season of intercollegiate competition.

The Cardinals competed in the Metro Conference and were coached by Denny Crum.

The team played home games at Freedom Hall.

The team completed a 33–3 record and brought Louisville basketball their first NCAA national championship when they defeated UCLA 59–54, led by Darrell Griffith and his 23 points.

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