The 1980–81 Albanian National Championship was the 42nd season of the Albanian National Championship, the top professional league for association football clubs, since its establishment in 1930.
It was contested by 14 teams, and Partizani won the championship.
Note: "17 Nëntori" is Tirana, "Labinoti" is Elbasani, "Lokomotiva Durrës" is Teuta and "Traktori" is Lushnja.
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