The 1980–81 FIBA European Champions Cup was the 24th season of the European top-tier level professional basketball club competition FIBA European Champions Cup (now called EuroLeague).

The Final was held at the Hall Rhénus, in Strasbourg, France, on March 26, 1981.

In a tightly contested game, Maccabi Elite Tel Aviv defeated Sinudyne Bologna, by a result of 80–79.

March 26, Hall Rhénus, Strasbourg