The 1980–81 season of the Moroccan Throne Cup was the 25th edition of the competition.
Wydad Athletic Club won the cup, beating CODM Meknès 2–1 in the final,[1] played at the Prince Moulay Abdellah Stadium in Rabat.
Wydad Athletic Club won the title for the fourth time in their history.
The final was played between the two winning semi-finalists, Wydad Athletic Club and CODM Meknès, on 16 September 1980 at the Prince Moulay Abdellah Stadium in Rabat.