1980–81 Northern Premier League

[1] The League featured twenty-two clubs.

The following club left the League at the end of the previous season: The following club joined the League at the start of the season: Challenge Cup Cup: Northern Premier League Shield: Between Champions of NPL Premier Division and Winners of the NPL Cup.

As Runcorn won both the Northern Premier League and the Challenge Cup, Mossley qualified as 2nd placed team of the NPL.

Only one of the twenty-two Northern Premier League clubs reached the second round: Second Round One of the twenty-two Northern Premier League clubs reached the fourth round: Fourth Round At the end of the thirteenth season of the Northern Premier League, Runcorn applied to join the Alliance Premier League and were successful.

The following club left the League at the end of the season: The following club joined the League the following season: