The 1980–81 Oklahoma City Chiefs men's basketball team represented Oklahoma City University in the 1980–81 NCAA Division I men's basketball season as a member of the Midwestern City Conference.
They finished the season 14-15 overall, tied for second in the MCC regular season title with a 7–4 record and won the 1981 Midwestern City Conference men's basketball tournament.
However, the conference did not receive a bid to the NCAA tournament.
They played their home games at Frederickson Fieldhouse in Oklahoma City, Oklahoma.
This article related to sports in Oklahoma is a stub.