The final saw Tottenham Hotspur defeat Manchester City in the first Wembley replay.
[1] Teams from the Football League Third and Fourth Division entered in this round plus Altrincham, Dagenham, Mossley and Scarborough were given byes.
Teams from the Football League First and Second Division entered in this round.
The sixth round of FA Cup games were played on 7 March 1981.
Occasional highlights of replays would be shown on either the BBC or ITV.