This page details the qualifying process for the 1980 Africa Cup of Nations in Nigeria.
Nigeria, as hosts, and Ghana, as title holders, qualified automatically.
Mauritius won by away goals rule after 2–2 on aggregate.
Guinea won 6–5 on penalty shootout after 3–3 on aggregate.
Kenya advanced: Tunisia were disqualified after they were banned from CAF competitions for two years for walking off the pitch to protest the officating during the third-place match of the 1978 African Cup of Nations.