The 1980 Cal State Fullerton Titans football team represented California State University, Fullerton as a member of the Pacific Coast Athletic Association (PCAA) during the 1980 NCAA Division I-A football season.
Led by first-year head coach Gene Murphy, Cal State Fullerton compiled an overall record of 4–7 with a mark of 1–4 in conference play, placing in a three-way tie for fourth place in the PCAA.
The Titans played two home games for the third year in a row, both at Titan Field on the Cal State Fullerton campus.
The football team shared the stadium with the Cal State Fullerton Titans baseball from 1980 to 1982.
[12][13] The following Cal State Fullerton Titans were selected in the 1981 NFL draft.