The 1980 Holy Cross Crusaders football team was an American football team that represented the College of the Holy Cross as an independent during the 1980 NCAA Division I-A football season.
Neil Wheelwright returned for his fifth year as head coach.
The team compiled a record of 3–8.
[1] All home games were played at Fitton Field on the Holy Cross campus in Worcester, Massachusetts.
Statistical leaders for the 1980 Crusaders included:[13]