The 1980 Major League Baseball season concluded with the Philadelphia Phillies winning their first World Series championship.
A strike during April 1–8 caused the final eight days of spring training to be canceled, but did not impact the regular season schedule.
*Denotes walk-off Thursday Night Baseball aired on USA Network.
ABC aired Monday Night Baseball, the All-Star Game, and both League Championship Series.
NBC televised the weekend Game of the Week and the World Series.