The 1980 U.S. Clay Court Championships was a men's Grand Prix and women's Colgate Series tennis tournament held at the Indianapolis Sports Center in Indianapolis in the United States and played on outdoor clay courts.

It was the 12th edition of the tournament and was held from August 4 through August 10, 1980.

Eighth-seeded José Luis Clerc and top-seeded Chris Evert-Lloyd won the singles titles.

[3][4] José Luis Clerc defeated Mel Purcell 7–5, 6–3 Chris Evert-Lloyd defeated Andrea Jaeger 6–4, 6–3 Kevin Curren / Steve Denton defeated Wojciech Fibak / Ivan Lendl 3–6, 7–6, 6–4 Anne Smith / Paula Smith defeated Virginia Ruzici / Renáta Tomanová 4–6, 6–3, 6–4