Defending champion John McEnroe defeated Björn Borg in the final, 7–6(7–4), 6–1, 6–7(5–7), 5–7, 6–4 to win the men's singles tennis title at the 1980 US Open.

The final is often ranked among the best matches in tennis history,[1][2] and was central to the Borg–McEnroe rivalry.

[3][2] It was the first successful US Open men's singles title defense since the start of the Open Era in 1968.

The seeded players are listed below.

John McEnroe is the champion; others show the round in which they were eliminated.