The 1981–82 season was the 67th season of the Isthmian League, an English football competition.
Leytonstone & Ilford were champions, winning their first Isthmian League title two years after merging.
Bognor Regis Town were transferred from the Southern Football League and won promotion to the Premier Division at the first attempt.
Camberley Town left the league at the end of the season.
The Premier Division consisted of 22 clubs, including 20 clubs from the previous season and two new clubs, promoted from Division One: