The 1981 Critérium du Dauphiné Libéré was the 33rd edition of the cycle race and was held from 26 May to 2 June 1981.

The race started in Grenoble and finished in Avignon.

The race was won by Bernard Hinault of the Renault team.

[2] Ten teams, containing a total of 99 riders, participated in the race:[2]