Their playoff run ended in the NLCS against the Los Angeles Dodgers, with Rick Monday hitting a ninth-inning solo home run in game 5, subsequently referred to as "Blue Monday" by Expos fans.
This was also their last time winning a playoff series until 2019, which they won the Wild Card game.
The season was separated into two halves due to the 1981 Major League Baseball strike.
After holding spring training at City Island Ball Park in Daytona Beach, Florida, from 1973 to 1980, the Expos returned to West Palm Beach Municipal Stadium in West Palm Beach, Florida – a facility they shared with the Atlanta Braves – for spring training in 1981.
Infielders Coaches Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.