The 1981 Northern Illinois Huskies football team represented Northern Illinois University as a member of the Mid-American Conference (MAC) during 1981 NCAA Division I-A football season.
Led by second-year head coach Bill Mallory, the Huskies compiled an overall record of 3–8 with a mark of 2–7 in conference play, placing ninth in the MAC.
Northern Illinois played home games at Huskie Stadium in DeKalb, Illinois.
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