The 1981 Western Illinois Leathernecks football team represented Western Illinois University as a member of the Association of Mid-Continent Universities during the 1981 NCAA Division I-AA football season.
They were led by third-year head coach Pete Rodriguez and played their home games at Hanson Field.
The Leathernecks finished the season with a 5–6 record overall and a 2–1 record in conference play, making them conference co-champions with Eastern Illinois and Northern Iowa.
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