The circuit had been slightly modified from its original configuration the year before, with the pit lane extended to place the entrance before the final chicane, and a short new section of track eliminating the extremely tight hairpin at Turn Five.
Defending Champion Keke Rosberg was twelfth, Alain Prost thirteenth and Niki Lauda eighteenth, while the non-turbocharged cars of Marc Surer and Alboreto were fifth and sixth.
American Eddie Cheever, in the only competitive ride of his F1 career with Renault, was in seventh spot, six places ahead of his highly regarded teammate.
The boats on the Detroit River, the blaring music and the floods of people from the downtown hotels created quite an atmosphere, inevitably bringing comparisons to Monaco, as the Long Beach event often did.
On lap five, Cheever retired with ignition failure, de Angelis forfeited third place with a broken gearbox and Piercarlo Ghinzani abandoned his Osella in the pits with an overheating engine.
John Watson, having started in 21st position on the grid, was now in fourth, making his regular charge through an American Grand Prix field.
Alboreto's teammate, American Danny Sullivan, in his only season of Formula One, retired at the halfway point of the race when his engine failed.
The tight downtown street course took away much of the advantage of the turbocharged cars, and Alboreto's win for Cosworth-Ford was the last of the season's three non-turbo victories.