In their fifth year under head coach Bill Russo, the Leopards compiled a 6–5 record.
[1] John Anderson and Ryan Priest were the team captains.
[2] This was Lafayette's final year as an independent, before joining the Colonial League.
Future league football opponents on the Leopards' 1985 schedule included Bucknell, Colgate, Lehigh and Towson.
Lafayette played home games at Fisher Field on College Hill in Easton, Pennsylvania.