The 1988 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as a member of the Western Football Conference (WFC) during the 1988 NCAA Division II football season.
Led by second-year head coach Lyle Setencich, Cal Poly compiled an overall record of 5–4–1 with a mark of 3–3 in conference play, placing fourth in the WFC.
[1] The team outscored its opponents 238 to 145 for the season.
The Mustangs played home games at Mustang Stadium in San Luis Obispo, California.
[10][11] The following Cal Poly Mustang players were selected in the 1989 NFL draft.