The 1988 Campionati Internazionali di Sicilia was a men's tennis tournament played on outdoor clay courts in Palermo, Italy that was part of the 1988 Nabisco Grand Prix.

It was the tenth edition of the tournament and took place from 26 September until 2 October 1988.

First-seeded Mats Wilander won the singles title.

Mats Wilander defeated Kent Carlsson 6–1, 3–6, 6–4 Carlos di Laura / Marcelo Filippini defeated Alberto Mancini / Christian Miniussi 6–2, 6–0