The 1988 Southern Illinois Salukis football team was an American football team that represented Southern Illinois University (now known as Southern Illinois University Carbondale) in the Gateway Collegiate Athletic Conference (GCAC) during the 1988 NCAA Division I-AA football season.
Under first-year head coach Rick Rhoades, the team compiled a 4–7 record (2–4 against conference opponents) and tied for fifth place in the conference.
[1] The team played its home games at McAndrew Stadium in Carbondale, Illinois.