The 1988 U.S. Women's Open was the 43rd U.S. Women's Open, held July 21–24 at the Five Farms East Course of Baltimore Country Club in Lutherville, Maryland, a suburb north of Baltimore.

Liselotte Neumann won her only major title, three strokes ahead of runner-up Patty Sheehan.

At age 22, Neumann was the youngest professional to date to win the title, second by two months to 1967 champion Catherine Lacoste, an amateur who won less than a week after turning 22.

Sixty years earlier, the East Course hosted the PGA Championship in 1928, won by Leo Diegel.

He stopped four-time defending champion Walter Hagen in the quarterfinals, ending his winning streak at 22 matches.