The 1988 Virginia Slims of San Diego was a women's tennis tournament played on outdoor hard courts at the San Diego Tennis & Racquet Club in San Diego, California, in the United States and was part of the Category 2 tier of the 1988 WTA Tour.

The tournament ran from August 1 through August 7, 1988.

Second-seeded Stephanie Rehe won the singles title and earned $17,000 first-prize money.

[1][2] Stephanie Rehe defeated Ann Grossman 6–1, 6–1 Patty Fendick / Jill Hetherington defeated Betsy Nagelsen / Dianne van Rensburg 7–6(12–10), 6–4