The 1989–90 season of the European Cup Winners' Cup was won for the only time by Sampdoria in the final against Anderlecht, 2–0 at Nya Ullevi in Gothenburg, on 9 May 1990.

English clubs were still banned from Europe following the Heysel Stadium disaster, meaning Liverpool missed out on a place, but would have a representative again the following season.

Real Valladolid won 6–0 on aggregate.

BFC Dynamo won 4–2 on aggregate.

Borussia Dortmund won 3–1 on aggregate.

Torpedo Moscow won 6–0 on aggregate.

Notes 0–0 on aggregate; Monaco won 3–1 on penalties.