For the second Grand Prix in a row, the Onyx of Bertrand Gachot topped the time sheets in Friday morning's pre-qualifying session.
The Zakspeed pairing of Bernd Schneider and Aguri Suzuki were tenth and twelfth, with no success at this stage since the first race of the season.
Maurício Gugelmin qualified sixth, but his March developed a water-related problem moments before the race, forcing him to start from the pit lane.
On lap 5 the race order was Senna, Prost, Mansell, the Williams pair of Thierry Boutsen and Riccardo Patrese, and Alessandro Nannini in the Benetton.
Patrese overtook teammate Boutsen for third, before suffering a huge accident on lap 20 when a burst radiator sprayed water onto his rear wheels, causing him to spin off into the tyre barrier at Club Corner.
With Prost and Mansell pulling away, Nelson Piquet moved into third in his Lotus on lap 23, ahead of Boutsen, Philippe Alliot in the Larrousse-Lola and Jean Alesi in the Tyrrell.
Boutsen dropped back with a rear puncture while Alesi spun off at Club Corner on lap 29, at which point Prost led Mansell by 3.2 seconds, followed by Piquet, Nannini, Gugelmin and Alliot.