A pumped-up Colm O'Neill hit Meath's Mick Lyons, and was dismissed from the field of play.
Cork's strategy of isolating Meath's extra player worked well as Shay Fahy dominated midfield.
Cork's All-Ireland SFC final victory was the second in succession, the first and only time in the team's history to have retained the title.
The win gave the team a sixth All-Ireland SFC title overall, and put them fourth in their own right on the all-time roll of honour.
In winning the All-Ireland SFC title against Meath, Cork achieved a rare double, as the Cork senior hurling team had earlier claimed the All-Ireland SHC title against Galway.