The 1991–92 UEFA Cup was the 21st season of Europe's then-tertiary club football tournament organised by UEFA.

The final was played over two legs at Stadio Delle Alpi, Turin, Italy, and at Olympisch Stadion, Amsterdam, Netherlands.

The competition was won by Dutch club Ajax, who defeated Torino of Italy on away goals after an aggregate result of 2–2 to claim their first UEFA Cup title.

The victory made Ajax only the second team – after Torino's city rivals Juventus – to have won all three major European trophies (European Cup/UEFA Champions League, UEFA Cup/UEFA Europa League, and the Cup Winners' Cup).

As the only English team in the tournament due to lost coeffecient following the five-year ban for the Heysel disaster during the 1985 European Cup final, and being given an additional year of exclusion, Liverpool made their comeback in continental competition for the first time since then.

A total of 64 teams from 32 UEFA member associations participated in the 1991–92 UEFA Cup, all entering from the first round over six knock-out rounds.

The association ranking based on the UEFA country coefficients is used to determine the number of participating teams for each association: For the 1991–92 UEFA Cup, the associations are allocated places according to their 1990 UEFA country coefficients, which takes into account their performance in European competitions from 1985–86 to 1989–90.

Despite returning to European competitions the previous season, England's five-year ban was served during the period reflected in the ranking and had no score, so only one English club competed in the UEFA Cup.

2 This match was played in Klagenfurt, Austria due to the outbreak of the Croatian War of Independence.

3 This match was played in Istanbul, Turkey due to the deteriorating security situation in Yugoslavia that eventually turned into the Yugoslav Wars.

Match was played in Austria due to the outbreak of the Croatian War of Independence.

Match played at Estádio do Bessa instead of their regular stadium Estádio Engenheiro Vidal Pinheiro.

Sigma Olomouc won 6–0 on aggregate.

CSKA Sofia won on away goals.

Sporting Gijón won 3–2 on penalties.

Match was played in Turkey due to the deteriorating security situation in Yugoslavia that eventually turned into the Yugoslav Wars.

The top scorers from the 1991–92 UEFA Cup are as follows: