The 1991 Pittsburgh Pirates season was the 110th in franchise history; the 105th in the National League.

For the second consecutive season, the Pirates won the National League East title with a record of 98–64.

The Pirates finished the season with the best record in Major League Baseball.

During the season, John Smiley won 20 games – the last to do so for the Pirates in the 20th century.

Infielders Coaches 1991 Major League Baseball All-Star Game Note: G = Games played; AB = At bats; H = Hits; Avg.