The 1991 Southern Illinois Salukis football team was an American football team that represented Southern Illinois University (now known as Southern Illinois University Carbondale) in the Gateway Collegiate Athletic Conference (GCAC) during the 1991 NCAA Division I-AA football season.
Under third-year head coach Bob Smith, the team compiled a 7–4 record (4–2 against conference opponents) and tied for second place in the conference.
[1] The team played its home games at McAndrew Stadium in Carbondale, Illinois.