The 1991 Texas Southern Tigers football team represented Texas Southern University as a member of the Southwestern Athletic Conference (SWAC) during the 1991 NCAA Division I-AA football season.
Led by third-year head coach Wally Highsmith, the Tigers compiled an overall record of 5–5–1, with a mark of 3–3–1 in conference play, and finished tied for fourth in the SWAC.
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