The 75th running of the Tour of Flanders cycling classic was held on Sunday, 7 April 1991.

The race was the second leg of the UCI Road World Cup.

Edwig Van Hooydonck, Johan Museeuw, Rolf Sørensen ad Rolf Gölz broke away on Tenbosse in Brakel.

Van Hooydonck tried to drop his companions on the Muur van Geraardsbergen, before really going solo on the Bosberg, the ultimate climb of the day, and powering on to the finish.

The race started in Sint-Niklaas and finished in Meerbeke (Ninove) – totaling 261 km.