The 1992 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as a member of the Western Football Conference (WFC) during the 1992 NCAA Division II football season.
Led by sixth-year head coach Lyle Setencich, Cal Poly compiled an overall record of 4–5–1 with a mark of 2–3 in conference play, tying for fourth place in the WFC.
The WFC folded after 1992, in part because of a new National Collegiate Athletic Association (NCAA) rule that prohibited member institutions who competed at the NCAA Division I level in other sports to compete at the NCAA Division II level in football.
Four WFC members—Cal State Northridge, Sacramento State, Cal Poly, andSouthern Utah—joined with UC Davis as charter members of the Division-I American West Conference in 1993.
[11] The following Cal Poly Mustang players were selected in the 1993 NFL draft.