The defending champion Blue Jays defeated the White Sox, 4–2, to advance to the 1993 World Series which they would win 4–2 over the Philadelphia Phillies thanks to Joe Carter's dramatic three-run walk-off home run in Game 6.
The ALCS opened at Comiskey Park with a battle of aces, as Toronto threw Juan Guzmán against Chicago's Jack McDowell, the eventual 1993 American League Cy Young Award winner.
The game was scoreless until the top of the fourth inning, when Jays third baseman Ed Sprague stroked a triple to right field that scored John Olerud and Paul Molitor.
The White Sox took a 3–2 lead in the bottom of the fourth inning with RBI base hits by Ozzie Guillén and Tim Raines, but Toronto stormed back in its half of the fifth with a two-run double by Olerud and a run-scoring single by Molitor.
The Blue Jays got a run in the bottom half of the frame when Henderson doubled, stole third, and scored on a Devon White single, but Hentgen was pulled in the fourth after giving up back-to-back base hits.
The South Siders took a 2–0 lead in the top of the second thanks to a home run by Johnson, but Toronto came back in the third with an RBI double from Alomar and a two-run single by Joe Carter, after which Pale Hose skipper Gene Lamont yanked Bere and replaced him with Tim Belcher.
In the ninth, Ward entered to close out the game and Ventura greeted him with a two-run shot, but he maintained his composure and struck out Jackson to give Toronto a 3–2 ALCS lead.
ChiSox reserve outfielder Warren Newson tagged Ward for a homer in the ninth, but the Jays closer recovered and induced a flyout from Raines, sealing the game 6–3 and Toronto's second American League pennant in a row.